Phytochemicals as antioxidant prophylactic agents in functional foods displayed a sustainable prevention for various metabolic ailments. Recent studies examining the oral and renoprotective activities of nutraceuticals have emphasized their supporting role in the management of diabetes and its complications. In this context, the current study encompasses the characterization of green tea phytochemicals, its effects on the energy metabolism of HEK-293 cell and on erythrocytes peroxidation. In the same pipeline, the anti-microbial effects of FPP® have been assessed on Streptococcus mutans, Streptococcus mitis and Lactobacil/us acidophilus. A randomized clinical trial has also been conducted at the Cardiac Centre, SSRNH Hospital, to assess how FPP (fermented papaya preparation)could affect carbonyl accumulation in pre-diabetic patients\ Our previous reports have illustrated the bioefficacy (of green tea and FPP® to modulate distinctive markers of diabetes mellitus and cardiovascular diseases in a randomized pre-diabetic Mauritian cohort. Results suggested that 6 g of FPP and 3 cups of green tea day for a period of 14 weeks would improve the health status of pre-diabetic patients. However, prevention and therapeutic strategies required a profound understanding about how dietary antioxidants interact with reactive radical species, which might be a causative agent of metabolic syndrome. Consequently, a free radical-induced hemolysis assay has been designed to understand how FPP® could scavenge peroxyl radicals in vitro.