Mauritius Research Repository

A custom genotyping array reveals population-level heterogeneity for the genetic risks of prostate cancer and other cancers in Africa

Version: 1, Uploaded by: Administrator, Date Uploaded: 25 November 2022

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Reference (Identifier)

GS-00515

Title

A custom genotyping array reveals population-level heterogeneity for the genetic risks of prostate cancer and other cancers in Africa

Broad Theme Classification

1. Natural Sciences

Second Level Classification

1.2 Computer and Information Sciences

Country Specific Sectors

28. Other

Author Name

Professor Maxine Harlemon

Institution

Georgia Institute of Technology

Co-Author 1 Name

Olabode Ajayi

Co-Author 2 Name

Paidamoyo Kachambwa

Co-Author 3 Name

Michelle S. Kim

Co-Author 4 Name

Corinne N. Simonti

Co-Author 5 Name

Melanie H. Quiver

Co-Author 6 Name

Desiree C. Petersen

Co-Author 7 Name

Anuradha Mittal

Co-Author 8 Name

Pedro W Fernandez

Co-Author 9 Name

Ann W. Hsing

Co-Author 10 Name

Dr. Shakuntala Baichoo

Co-Author 10 Institution

University of Mauritius

Co-Author 11 Name

Ilir Agalliu

Co-Author 12 Name

Mohamed Jalloh

Co-Author 13 Name

Serigne M. Gueye

Co-Author 14 Name

Nana Yaa F. Snyper

Co-Author 15 Name

Ben Adusei

Co-Author 16 Name

James E. Mensah

Co-Author 17 Name

Afua O. D. Abrahams

Co-Author 18 Name

Akindele O. Adebiyi

Co-Author 19 Name

Akin T. Orunmuyi

Co-Author 20 Name

Oseremen I. Aisuodionoe-Shadrach

Co-Author 21 Name

Maxwell M. Nwegbu

Co-Author 22 Name

Maureen Joffe

Co-Author 23 Name

Wenlong C. Chen

Co-Author 24 Name

Hayley Irusen

Co-Author 25 Name

Alfred I. Neugut

Co-Author 26 Name

Yuri Quintana

Co-Author 27 Name

Moleboheng Seutloali

Co-Author 28 Name

Mayowa B. Fadipe

Co-Author 29 Name

Christopher Warren

Co-Author 30 Name

Marcos H. Woehrmann

Co-Author 31 Name

Peng Zhang

Co-Author 32 Name

Chrissie M. Ongaco

Co-Author 33 Name

Michelle Mawhinney

Co-Author 34 Name

Jo McBride

Co-Author 35 Name

Caroline V. Andrews

Co-Author 36 Name

Marcia Adams

Co-Author 37 Name

Elizabeth Pugh

Co-Author 38 Name

Timothy R. Rebbeck

Co-Author 39 Name

Lindsay N. Petersen

Co-Author 40 Name

Joseph Lachance

Page Range

2956-2966

Date Published

1 July 2020

Abstract

Although prostate cancer is the leading cause of cancer mortality for African men, the vast majority of known disease associations have been detected in European study cohorts. Furthermore, most genome-wide association studies have used genotyping arrays that are hindered by SNP ascertainment bias. To overcome these disparities in genomic medicine, the Men of African Descent and Carcinoma of the Prostate (MADCaP) Network has developed a genotyping array that is optimized for African populations. The MADCaP Array contains more than 1.5 million markers and an imputation backbone that successfully tags over 94% of common genetic variants in African populations. This array also has a high density of markers in genomic regions associated with cancer susceptibility, including 8q24. We assessed the effectiveness of the MADCaP Array by genotyping 399 prostate cancer cases and 403 controls from seven urban study sites in sub-Saharan Africa. Samples from Ghana and Nigeria clustered together, while samples from Senegal and South Africa yielded distinct ancestry clusters. Using the MADCaP array, we identified cancer-associated loci that have large allele frequency differences across African populations. Polygenic risk scores for prostate cancer were higher in Nigeria than in Senegal. In summary, individual and population-level differences in prostate cancer risk were revealed using a novel genotyping array.

Keywords

Africa,genomic medicine,genotyping array,population genetics,prostate cancer

Language

English

Publisher

American Association for Cancer Research

Content Classification

Journal Article

Note/Remarks

Source: Google Scholar

Date Uploaded

25 November 2022

Size

File Format

Hyperlink

Journal

Cancer Research

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A custom genotyping array reveals population-level heterogeneity for the genetic risks of prostate cancer and other cancers in Africa

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A custom genotyping array reveals population-level heterogeneity for the genetic risks of prostate cancer and other cancers in Africa

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