Synthesis of Diketopiperazines Containing Prolinyl Unit—Cyclo (L-prolinyl-L-leucine), Cyclo (L-prolinyl-L-isoleucine) and Cyclo (L-tryptophyl-L-proline).
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26 November 2022
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Diketopiperazines cyclo(L-prolinyl-L-isoleucine) 4a, cyclo(L-prolinyl-L-leucine) 4b and cyclo(L-tryptophyl-L-proline) 6 were prepared from their respective suitably protected amino acid derivatives by standard peptide chemistry. Cyclo(L-(4-hydroxyprolinyl)-L-phenylalanine) 3, 4a and cycle(L-prolinyl-L-tyrosine) 5 were tested for their antibacterial activity.
