Studies towards Use of Di-tert-butyl-dicarbonate Both as a Protecting and Activating Group in the Synthesis of Dipeptides
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28 November 2022
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Amide formation from amino acids was achieved in an easy and convenient one-pot procedure in chloroform or tetrahydrofuran as solvent using di-tert-butyl dicarbonate both as a protecting and an activating agent in the absence of a catalyst or coupling reagent. A number of dipeptide has been thus synthesized in good yields. The structures of the dipeptides were confirmed by IR, NMR and mass spectral data.
