Phenolic constituents and antioxidant efficacies of some Mauritian traditional preparations commonly used against cardiovascular disease
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29 August 2022
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The surge of interest in traditional medicine has prompted research into the phenolic composition and antioxidant activity of
Adansonia digitata, Catharanthus roseus, Eugenia uniflora, Phyllantus emblica and Terminalia arjuna which are commonly used as traditional remedies against cardiovascular diseases in Mauritius. The polyphenolic profiles of these 5 herbal preparations (prepared according to traditional medicine sellers’ recipe) were screened. HPLC analyses showed that the plant extracts had complex flavonoid profiles with interesting amounts of quercetin, myricetin and kaempferol conjugates. Flavan-3-ol derivatives such as (+) catechin, (-) epicatechin, catechin gallates, procyanidins B1 and B2 were identified in most preparations. The highest total phenolic (34.9 ± 0.92 mg/g FW) and proanthocyanidin (15.0 ± 0.416 mg/g FW) contents were measured in T.arjuna whilst E.uniflora had the highest flavonoid composition (7.8 ± 0.04 mg/g FW).
The antioxidant and free radical scavenging potential were evaluated using trolox equivalent antioxidant assay (TEAC),
ferric reducing antioxidant power (FRAP), scavenging of hypochlorous acid, deoxyribose assay and inhibition of microsomal lipid peroxidation. T.arjuna extract exhibited the most powerful antioxidant capacity in the systems studied with a TEAC value of 306.92 ± 2.37 µmol/g FW and calculated IC50s of 1.5 ± 0.09 mg/ml and 0.2 ± 0.01mg/ml in
scavenging hypochlorous acid and in inhibiting microsomal lipid peroxidation respectively. The antioxidant activities correlated strongly with the total phenolic content of the plant extracts.
Keywords
Antioxidants,cardiac dysfunctions,free radicals,oxidative damage,phenolics,traditional medicine in Mauritius
