Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment
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29 August 2022
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Apoptosis is a critical defense mechanism against the formation and progression of cancer and exhibits
distinct morphological and biochemicaltraits. Targeting apoptotic pathways becomes an intriguing strategy for the development of chemotherapeutic agents particularly ifthe process is selective to cancer cells.
Marine natural products have become important sources in the discovery of antitumour drugs, especially
when recent technological and methodological advances have increased the scope of investigations of
marine organisms. A high number of individual compounds from diverse organisms have induced apoptosis in several tumour cell lines via a number of mechanisms. Here, we review the effects of selected
marine natural products and their synthetic derivatives on apoptosis signalling pathways in association
with their pharmacological properties. Providing an outlook into the future, we also examine the factors that contribute to new discoveries and the difficulties associated with translating marine-derived
compounds into clinical trials.