Detecting membrane progestin receptor (mPR)-interacting compounds from coral seawater in Mauritius
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29 August 2022
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Progestins are key regulators of reproduction. Although the physiological e ects of progesterone are mediated by regulating the expression of genes associated with nuclear progesterone receptors (nPRs), new insights into proges-terone activity was provided when membrane progestin receptors (mPRs) were identi ed. Also, mPRs have been shown to be a novel target for endocrine disrupting chemicals (EDCs). Natural hormonal compounds or arti cial chemicals that interact with mPRs were sought as possible novel pharmaceuticals or EDCs.