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Punica granatum L. mesocarp suppresses advanced glycation end products (AGEs)- and H2O2-induced oxidative stress and pro-inflammatory biomarkers

Version: 1, Uploaded by: MRIC Publisher 02, Date Uploaded: 28 October 2021

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Reference (Identifier)
MRR-21-00124
Title

Punica granatum L. mesocarp suppresses advanced glycation end products (AGEs)- and H2O2-induced oxidative stress and pro-inflammatory biomarkers

Broad Theme Classification
1. Natural Sciences
Second Level Classification
1.6 Biological Sciences
Country Specific Sectors
28. Other
Author Name
Dr. Piteesha Ramlagan
Institution
University of Mauritius
Co-Author 1 Name
Dr. Philippe Rondeau
Co-Author 1 Institution
Université de La Réunion
Co-Author 2 Name
Ms. Cynthia Planesse
Co-Author 2 Institution
Université de La Réunion
Co-Author 3 Name
Associate Professor Vidushi Shradha Neergheen
Co-Author 4 Name
Dr. Shameem Fawdar
Co-Author 4 Institution
University of Mauritius
Co-Author 5 Name
Professor Emmanuel Bourdon
Co-Author 5 Institution
Université de La Réunion
Co-Author 6 Name
Professor Theeshan Bahorun
Co-Author 6 Institution
University of Mauritius
Page Range
1-12
Date Published
20 December 2016
Abstract
The protective potential of pomegranate (Punica granatum L.) mesocarp extract (PME) on a cell model mimicking diabetes-like oxidative stress exposed to advanced glycation end products (AGEs) and hydrogen peroxide (H2O2) was investigated. The polyphenolic antioxidant rich PME afforded protection to erythrocytes from AAPH radical-induced lysis and significantly reduced (P < 0.001) ROS production in 3T3-L1 preadipocytes by preventing AGEs-modulated decrease in intrinsic antioxidant enzymatic activities and by reducing NOX1 expression. PME significantly inhibited protein carbonyl and AOPP levels following their increase in the presence of AGEs and H2O2 (P < 0.05). It exerted an anti-inflammatory effect on preadipocytes by suppressing IL-6 secretion. PME down-regulated the over-expression of pro-inflammatory mediators NFκB, iNOS and IL-6 post-AGEs treatment and concomitantly down-regulated the expression of AGEs receptor CD36 in the presence of AGEs. PME decreases oxidative stress and inflammation at adipose tissue level with the propensity to mitigate obesity-related disorders such as insulin resistance and type II diabetes.
Keywords
AGEs,Antioxidants,Oxidative stress,Pomegranate,Preadipocytes
Language
English
Publisher
Elsevier
Content Classification
Journal Article
Note/Remarks
Funded under the NRC/NRIC of the MRC/MRIC
Date Uploaded
28 October 2021
Size
1
File Format
1
Hyperlink
https://www.sciencedirect.com/science/article/abs/pii/S175646461630398X?via%3Dihub
Journal
Journal of Functional Foods
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