Regulation of cancer cell signaling pathways as key events for therapeutic relevance of edible and medicinal mushrooms
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Uploaded by: MRIC Publisher 02,
Date Uploaded:
26 October 2021
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Mushrooms, both edible and medicinal have received considerable attention against
cancer due to their polysaccharides, polysaccharides-protein complexes and low
molecular weight secondary metabolites content. Every year, millions of people die
because of this disease. Existing cancer therapies are poised with questions of
efficacy, toxicity and adverse effects, hence justifying the search for finding new,
alternative and efficient means to fend off the disease. Mushrooms and their derived
active molecules can prevent oncogenesis and tumour metastasis via directly
inhibiting tumour cells growth or indirectly improving immunity functions and by
acting as chemotherapy adjuvants. While the mechanisms of such effects are not
fully known, the roles of the bioactive compounds on cell signaling pathways
involved in the promotion and progression of the disease appear to be key,
particularly in view of their role(s) in multiple cellular processes, including cell
survival, proliferation, and differentiation. This review discusses the aberrant cell
signaling pathways involved in inhibition of tumour cell growth as target for
mushrooms and their bioactive compounds as well as the associated challenges for
the molecules therein to be successfully considered as preventive/therapeutic agents
against cancer.
